On Tue, 15 Apr 2003 22:29:18 +0200, "Michalw" <m...@i...net.pl>
wrote:

>www.kobiety.org
>

Radze rowniez zapoznac sie z tym tekstem :

Eur J Contracept Reprod Health Care 1998 Dec;3(4):169-78

A double-blind study comparing the contraceptive efficacy,
acceptability and safety of two progestogen-only pills containing
desogestrel 75 micrograms/day or levonorgestrel 30 micrograms/day.
Collaborative Study Group on the Desogestrel-containing
Progestogen-only Pill.

OBJECTIVE: To compare the contraceptive efficacy, bleeding pattern,
acceptability and safety of desogestrel 75 micrograms/day (Cerazette)
as a progestogen-only formulation to levonorgestrel 30 micrograms/day
in healthy female subjects. METHODS: In a double-blind, randomized,
group-comparative, multicenter trial, 989 subjects were randomized to
desogestrel 75 micrograms/day and 331 to levonorgestrel 30
micrograms/day. The women were observed during 13 consecutive
treatment periods of 28 days. RESULTS: The Pearl indices for
in-treatment pregnancies, excluding gross non-compliance, were 0.14
(one pregnancy in 727 woman-years) in the desogestrel group and 1.17
(three pregnancies in 257 woman-years) in the levonorgestrel group.
Using the 90-day reference period for assessing the bleeding pattern,
desogestrel users had a higher incidence of amenorrhea and infrequent
bleeding on the one hand, and of frequent bleeding and prolonged
bleeding on the other hand, at the beginning of the study period. In
contrast to the levonorgestrel group, a tendency towards less bleeding
over time was observed in the desogestrel group. The frequency and
pattern of adverse experiences were comparable for desogestrel 75
micrograms/day and levonorgestrel 30 micrograms/day. CONCLUSIONS:
Desogestrel 75 micrograms/day is a reliable and safe progestogen-only
pill with a contraceptive efficacy superior to levonorgestrel 30
micrograms/day. These was a similar overall acceptability of
desogestrel 75 micrograms/day and levonorgestrel 30 micrograms/day.

PMID: 10036599

Przepraszam za obszerny cytat . Ale zrodla czyta sie lepiej w orginale
(no prawie).

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dradam