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Lepiej zasięgnąć porady lekarskiej.


Effects of omega-3 fatty acids on serum markers of cardiovascular disease
risk: A systematic review.
Atherosclerosis. 2006 Mar
Greater fish oil consumption has been associated with reduced CVD risk,
although the mechanisms are unclear. Plant-source oil omega-3 fatty acids
(ALA) have also been studied regarding their cardiovascular effect. We
conducted a systematic review of randomized controlled trials that evaluated
the effect of consumption of fish oil and ALA on commonly measured serum CVD
risk factors, performing meta-analyses when appropriate. Combining 21 trials
evaluating lipid outcomes, fish oil consumption resulted in a summary net
change in triglycerides of -27 (95% CI -33, -20)mg/dL, in HDL cholesterol of
+1.6 (95% CI +0.8, +2.3)mg/dL, and in LDL cholesterol of +6 (95% CI +3,
+8)mg/dL.
____There was no effect of fish oil on total cholesterol_____. Across
studies, higher fish oil dose and higher baseline levels were associated
with greater reductions in serum triglycerides.


Treatment of hypertriglyceridemia with omega-3 fatty acids: a systematic
review.
J Am Acad Nurse Pract. 2004
PURPOSE: To (a) critically appraise available randomized controlled trials
(RCTs) addressing the efficacy of long-chain omega-3 fatty acids as
secondary agents for prevention of hypertriglyceridemia and (b) make
recommendations for clinical practice. DATA SOURCES: Two independent
reviewers examined all RCTs from 1994 to 2003 identified in several
databases, extracted data from each study, and used the previously tested
Boyack and Lookinland Methodological Quality Index (MQI) to determine study
quality. CONCLUSIONS: Ten studies reported long-chain omega-3 fatty acids to
be effective in the treatment of hypertriglyceridemia. The average decrease
in triglycerides was 29%, total cholesterol 11.6%, very low density
lipoprotein (VLDL) 30.2%, and low-density lipoprotein (LDL) 32.5%. One study
found LDLs to increase by 25%. The average increase in high-density
lipoprotein was 10%. The overall average MQI score was 36% (range = 26% to
54%). Many of the RCTs had serious shortcomings, including short duration,
lack of a power analysis, no intention-to-treat analysis, no report of blind
assessment of outcome, and lack of dietary control as a confounding
variable. IMPLICATIONS FOR PRACTICE: Overall study methodology was weak.
Although the evidence supporting use of long-chain omega-3 fatty acids in
the secondary prevention of hypertriglyceridemia is reasonably strong, until
there are larger RCTs of better methodological quality,
____it is not recommended that practitioners treat hypertriglyceridemia with
omega-3 fatty acid supplementation in lieu of lipid-lowering
medications._________