Skoro to jest lista SCI to troszke poczytajmy abstracty naukowych prac:

Liczba wypowiedzi w tym wątku: 2

1. Data: 2002-08-12 09:17:04

Temat: Skoro to jest lista SCI to troszke poczytajmy abstracty naukowych prac:
Od: "Jacek" <o...@p...com> szukaj wiadomości tego autora

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Pozdrawiam.
Jacek

High-fat diet prevents eating response and attenuates liver ATP decline in
rats given 2,5-anhydro-D-mannitol. Friedman, Mark I.; Koch, James E.;
Graczyk-Milbrandt, Grazyna; Ulrich, Patricia M.; Osbakken, Mary D. Monell
Chemical Senses Center, Philadelphia, PA, USA. American Journal of
Physiology (2002), 282(3, Pt. 2), R710-R714. CODEN: AJPHAP ISSN:
0002-9513. Journal written in English. CAN 136:385452 AN 2002:225323
CAPLUS (Copyright 2002 ACS)

Abstract

To assess whether feeding a high-fat diet prevents the eating response to
2,5-anhydro-D-mannitol (2,5-AM) by attenuating the decrease in liver ATP,
the authors examd. the effects of the analog on food intake, liver ATP
content, and hepatic phosphate metab. [using in vivo 31P-NMR spectroscopy
(NMRS)]. Injection (i.p.) of 300 mg/kg 2,5-AM increased food intake in rats
fed a high-carbohydrate/low-fat diet, but not in those fed
high-fat/low-carbohydrate (HF/LC) food. Liver ATP content decreased in all
rats given 2,5-AM compared with saline, but it decreased about half as much
in rats fed the HF/LC diet. NMRS on livers of anesthetized rats indicated
that feeding the HF/LC diet attenuates the effects of 2,5-AM on liver ATP by
reducing phosphate trapping. These results suggest that rats consuming a
high-fat diet do not increase food intake after injection of 2,5-AM, because
the analog is not sufficiently phosphorylated and therefore fails to
decrease liver energy status below a level that generates a signal to eat.

2

Will high-carbohydrate/low-fat diets reduce the risk of coronary heart
disease? Willett, Walter C. Departments of Nutrition and
Epidemiology, Harvard School of Public Health, Boston, MA, USA.
Proceedings of the Society for Experimental Biology and Medicine (2000),
225(3), 187-190. CODEN: PSEBAA ISSN: 0037-9727. Journal; General Review
written in English. CAN 134:70725 AN 2000:841216 CAPLUS
(Copyright 2002 ACS)

Abstract

A review with 21 refs. The author suggests several conclusions based on the
available evidence from studies of low-fat, high-carbohydrate diet effects
on coronary heart disease risk. First, coronary heart disease rates can be
dramatically reduced by nutritional means, but this will not be achieved by
replacing satd. fat with carbohydrates. Second, we should abandon
recommendations regarding the percentage of energy from fat and pejorative
refs. to fat or fatty foods. Finally, advice about dietary fat should focus
on replacement of satd. and trans fatty acids with unsatd. fats, including
sources of a-linolenic acids

3.

Treatment of hypertriglyceridemia by two diets rich either in unsaturated
fatty acids or in carbohydrates: Effects on lipoprotein subclasses,
lipolytic enzymes, lipid transfer proteins, insulin and leptin. Pieke,
B.; von Eckardstein, A.; Gulbahce, E.; Chirazi, A.; Schulte, H.; Assmann,
G.; Wahrburg, U. Institute of Arteriosclerosis Research, University of
Munster, Munster, Germany. International Journal of Obesity (2000),
24(10), 1286-1296. CODEN: IJOBDP ISSN: 0307-0565. Journal written in
English. CAN 134:100046 AN 2000:774045 CAPLUS (Copyright 2002
ACS)

Abstract

There is lack of agreement on which dietary regimen is most suitable for
treatment of hypertriglyceridemia, esp. if high triglyceride concns. are not
due to obesity or alc. abuse. We compared the effects on blood lipids of a
diet high in total and unsatd. fat with a low-fat diet in patients with
triglyceride concns. of >2.3 mmol/l. Nineteen non-obese male outpatients
with triglycerides ranging from 2.30 to 9.94 mmol/l received two consecutive
diets for 3 wk each: first a modified high-fat diet (39% total fat, 8% SFA,
15% monounsatd. fatty acids, 1.6% marine n-3 polyunsatd. fatty acids), and
then a low-fat diet (total fat 28%, carbohydrates 54%). The high-fat diet
significantly decreased triglycerides (-63%), total cholesterol (-22%), VLDL
cholesterol (-54%), LDL cholesterol (-16%), total apoC-III (-27%), apoC-III
in apoB contg. lipoproteins (apoC-III LpB; -31%) and in HDL (apoC-III
nonLpB; -29%), apoE in serum (-33%) and apoB-contg. lipoproteins
(nonHDL-E; -42%), LpA-I (-16%), insulin (-36%), and leptin (-26%) and
significantly increased the means of HDL cholesterol (+8%), LDL size (+6%),
lipoprotein lipase (LPL, +11%), hepatic lipase (+13%), and lecithin:
cholesterol acyltransferase (LCAT, +2%). The subsequent low-fat diet
increased triglycerides (+63%), VLDL cholesterol (+19%), apoC-III (+23%),
apoC-III LpB (+44%) apoC-III nonLpB (+17%), apoE (+29%) and nonH

4:
Reduced LDL particle size in children consuming a very-low-fat diet is
related to parental LDL-subclass patterns. Dreon, Darlene M.; Fernstrom,
Harriett A.; Williams, Paul T.; Krauss, Ronald M. Children's Hospital
Oakland, Oakland, CA, USA. American Journal of Clinical Nutrition
(2000), 71(6), 1611-1616. CODEN: AJCNAC ISSN: 0002-9165. Journal
written in English. CAN 133:134699 AN 2000:395424 CAPLUS
(Copyright 2002 ACS)

Abstract

A genetically influenced atherogenic lipoprotein phenotype characterized by
a predominance of small dense low-d. lipoprotein (LDL) particles (subclass
pattern B) can be induced by low-fat diets in healthy humans with large LDL
particles (pattern A). The genetic predisposition to subclass pattern B may
contribute to the susceptibility to the induction of this trait by low-fat
diets. The prevalence of pattern B in children is relatively low compared
with older individuals, but genetic susceptibility to this trait in
offspring can be inferred by its presence in their parents. Blood plasma
lipoproteins were analyzed 10 days after a change from the usual diet to
very-low-fat (10% fat)/high-carbohydrate diet in offspring (mean age 14 yr,
range 7-28 yr) of 22 families. The parental LDL-subclass patterns when
consuming the low-fat diet were: A´A mating (9 families with 19 children),
A´B mating (5 families with 10 children), and B´B mating (8 families with 21
children). The very-low-fat/high-carbohydrate diet produced greater
decreases in LDL particle size in offspring of B´B parents (-0.55ą0.16 nm)
and A´B parents (-0.48ą0.19 nm) than in offspring of A´A parents (0.14ą0.20
nm). The no. of children expressing pattern B with the 10% fat diet and the
proportion of children converting from pattern A to pattern B was greater in
offspring of B´B parents than in those with 1 or 2 pattern A parents. Thus,
very-low-fat/high-carbohydrate diet can induce expression of LDL-subclass
pattern B in genetically predis

5:
Replacement of carbohydrate by protein in a conventional-fat diet reduces
cholesterol and triglyceride concentrations in healthy normolipidemic
subjects. Wolfe, Bernard M. J.; Piche, Leonard A. Department of
Medicine, London, ON, Can. Clinical and Investigative Medicine
(1999), 22(4), 140-148. CODEN: CNVMDL ISSN: 0147-958X. Journal written
in English. CAN 132:151030 AN 1999:641791 CAPLUS (Copyright 2002
ACS)

Abstract

The effect on plasma lipid profiles of replacement of dietary carbohydrate
by low-fat, high-protein foods was studied in a cross-over randomized
controlled trial with 10 healthy, normolipidemic subjects. Subjects were
randomly allocated to either a low-protein (12%) or high-protein (22%)
wt.-maintaining diet for 4 wk and then switched to the alternate diet for 4
more weeks. The first 2 wk of each diet served as an adjustment/washout
period. Fat was maintained at 35% of energy, mean cholesterol intake at 230
mg per day and mean fiber intake at 24 g per day. Compliance was promoted
by the use of written dietary protocols based on the food preferences of the
subjects and weekly dietary consultation as required. Mean plasma levels of
total, very-low-d.-lipoprotein (VLDL), low-d.-lipoprotein (LDL), and
high-d.-lipoprotein (HDL) cholesterol, and of total and
very-low-d.-lipoprotein (VLDL) triglycerides were measured. Satiety levels
were self-rated on a 10-point scale. Consumption of the high- vs. the
low-protein diet resulted in significant redns. in mean plasma levels of
total cholesterol (3.8 v. 4.1 mmol/L, p < 0.05), VLDL cholesterol (0.20 v.
2.6 mmol/L, p < 0.02), LDL cholesterol (2.4 v. 2.6 mmol/L, p < 0.05), total
triglycerides (0.69 v. 0.95 mmol/L, p < 0.005) and VLDL triglycerides (0.35
v. 0.57 mmol/L, p < 0.001), as well as in the ratio of total cholesterol to
HDL cholesterol (3.1 v. 3.5, p < 0.01). A trend towards an increase in HDL
cholesterol (1.26 v. 1.21 mmol/L, p = 0.30) was obsd. but was not s

Warto na tego zwrcic uwage:

Dietary carbohydrates and triacylglycerol metabolism. Roche, Helen M.
Unit of Nutrition and Dietetics, Trinity Centre for Health Sciences, St
James's Hospital, Dublin, Ire. Proceedings of the Nutrition Society
(1999), 58(1), 201-207. CODEN: PNUSA4 ISSN: 0029-6651. Journal written
in English. CAN 131:144012 AN 1999:334258 CAPLUS (Copyright 2002
ACS)

Abstract

There is a growing body of scientific evidence which demonstrates that
plasma triacylglycerol (TAG) concn., esp. in the postprandial state, is an
important risk factor in relation to the development of CHD. Postprandial
hypertriacylglycerolemia is assocd. with a no. of adverse metabolic risk
factors, including the preponderance of small dense LDL, low HDL-cholesterol
concns. and elevated factor VII activity. Traditionally, a low-fat
high-carbohydrate diet was used to prevent CHD because it effectively
reduces plasma cholesterol concns., but this dietary regimen increases
plasma TAG concns. and reduces HDL-cholesterol concns. There is substantial
epidemiol. evidence which demonstrates that high plasma TAG and low plasma
HDL concns. are assocd. with an increased risk of CHD. Thus, there is
reason for concern that the adverse effects of low-fat high-carbohydrate
diets on TAG and HDL may counteract or negate the beneficial effect of
reducing LDL-cholesterol concns. Although there have been no prospective
studies to investigate whether reduced fat intake has an adverse effect on
CHD, there is strong epidemiol. evidence that reducing total fat intake is
not protective against CHD. On the other hand, high-fat diets predispose to
obesity, and central obesity adversely affects TAG metab. There is
substantial evidence that in free-living situations low-fat
high-carbohydrate diets lead to wt. loss, which in turn will correct insulin
resistance and plasma TAG metab. Clearly there is a need for prospective
studies to resolve the issue as to whether low-fat hig

I ten:
A very-low-fat diet is not associated with improved lipoprotein profiles in
men with a predominance of large, low-density lipoproteins. Dreon,
Darlene M.; Fernstrom, Harriett A.; Williams, Paul T.; Krauss, Ronald M.
Donner Laboratory, Lawrence Berkeley National Laboratory, University of
California, Berkeley, CA, USA. American Journal of Clinical Nutrition
(1999), 69(3), 411-418. CODEN: AJCNAC ISSN: 0002-9165. Journal written
in English. CAN 130:324600 AN 1999:171422 CAPLUS (Copyright 2002
ACS)

Abstract

Men with a predominance of blood plasma large LDL particles (phenotype A)
consuming high-fat diets (40-46% fat) show less lipoprotein change benefits
from eating low-fat diets (20-24% fat) than men with a high-risk lipoprotein
profile characterized by predominant small LDL (phenotype B). One-third of
phenotype A men consuming a high-fat diet may convert to phenotype B when
eating a low-fat diet. We investigated the effects of decreased dietary fat
in men with persistence of LDL phenotype A during both high- and low-fat
diet periods in crossover design. Thirty-eight men with phenotype A profile
after 4-6 wk on both high- and low-fat diets consumed for 10 days a 10%-fat
diet (2.7% satd.) with replacement of fat with carbohydrates and no change
in cholesterol content or ratio of polyunsatd. to satd. fats. In 26 men,
the phenotype A persisted (stable A group), whereas 12 converted to
phenotype B (change group). LDL cholesterol levels did not differ from
previous values for 20-24%-fat diets in either group, whereas in the change
group there were higher concns. of triacylglycerol and apolipoprotein B,
greater mass of HDL, large LDL-I, small LDL-III and LDL-IV, and HDL3, lower
concns. of HDL cholesterol and apolipoprotein A-I, and lower mass of large
LDL-I and HDL2. There was no apparent lipoprotein profile benefit from
decreasing dietary fat from 20-24% to 10% in men with large LDL particles:
the LDL-cholesterol concn. w

Serum lipid response to a high-caloric, high-fat diet in agricultural
workers during 12 months
D Brunner, J Weissbort, M Fischer, JE Bearman, K Loebl, S Schwartz and S
Levin

The effect of a gluttony diet in healthy subjects was studied over an
observation period of 12 months. Twenty-six agricultural workers, all of
them Yemenite Jews, received a high-caloric, high-fat diet, and the changes
in serum cholesterol (CH), high-density-lipoprotein- cholesterol,
triglycerides, and body weight were assessed. Yemenite Jews as a group are
characterized by low serum CH levels and by a low incidence of coronary
artery disease. For a period of 7 months the subjects received a diet of
4553 cal/day, more than double their original "Yemenite diet". After this
time they resumed their customary low-caloric diet for 3 months, and
thereafter for another 2 months they continued with the high-caloric food
regimen. The high-caloric, high- fat diet resulted in the expected increase
of serum CH. A similar increase of high-density lipoprotein-CH was found.
Serum triglyceride levels changed inversely to those of CH. It is suggested
that the altered relation of calories derived from carbohydrates to those
derived from fats brought about the decrease of triglycerides, and this
irrespective of the increased intake of carbohydrates and fats. The rather
small gain of body weight over the trial period--despite the doubled caloric
intake--is similar to other studies that showed that the ability of normal
individuals to gain weight through overeating varies considerably.

I już ostatni na dziś:

Change in dietary saturated fat intake is correlated with change in mass of
large low-density-lipoprotein particles in men
DM Dreon, HA Fernstrom, H Campos, P Blanche, PT Williams and RM Krauss
Children's Hospital Oakland Research Institute, CA, USA.

We tested whether nutrient intakes estimated from 4-d diet records were
associated with plasma lipoprotein subclasses in 103 men who were randomly
assigned to a low-fat (24% fat) and a high-fat (46% fat) diet for 6 wk each
in a crossover design. Postheparin plasma lipoprotein lipase (LPL) and
hepatic lipase (HL) activities were also determined in a subset of 43 men.
Changes in intake (ie, high fat minus low fat) of total saturated fatty
acids, as well as myristic (14:0) and palmitic (16:0) acids, were positively
correlated (P < 0.01) with increases in mass of large LDL particles
[measured by analytic ultra-centrifugation as mass of lipoproteins of
flotation rate (Sf) 7-12] and with LDL peak particle diameter and flotation
rate, but not with changes in LDL- cholesterol concentration. Changes in
total saturated fatty acids as well as myristic and palmitic acids were also
inversely associated with changes in HL activity (P < 0.05). With the
high-fat diet only, variation in dietary total saturated fatty acid intake
was inversely correlated (P < 0.01) with concentrations of small, dense LDL
of Sf 0- 5. This correlation was significant specifically for myristic acid
(P < 0.001). Stearic acid (18:0), monounsaturates, and polyunsaturates
showed no significant associations with lipoprotein concentrations. These
data indicate that a high saturated fat intake (especially 14:0 and 16:0) is
associated with increased concentrations of larger, cholesterol-enriched LDL
and this occurs in association with decreased HL activity.

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2. Data: 2002-08-19 09:46:17

Temat: Re: Skoro to jest lista SCI to troszke poczytajmy abstracty naukowych prac:
Od: "Jacek" <o...@p...com> szukaj wiadomości tego autora

"Jacek" <o...@p...com> wrote in message
news:aj7u7v$6fm$1@news.tpi.pl...
> Jako zdiagnozowany paranoik przez dyplomowanych fachowców z tej listy
> zapodaję dla poszukujących a nie plujących jadem nienawiści czlowieczków,
> kilka nowych prac pokazujących ze nauka idzie do przodu i 30 letnia
historia
> fobii tluszczowej zaczyna ukazywać swoją małość.
>
>
> Pozdrawiam.
> Jacek
No i coz? jak widać brak tu naukowcow czy jak?
Ta cisza jest zastanawiająca :)
Pa