Protonitazene

Opioids are central nervous system depressants. They typically produce a range of
effects including sedation, short-term pain relief, and respiratory depression
(breathing difficulty).

Respiratory depression often appears more quickly with novel synthetic
opioids (NSOs), increasing the risk of life-threatening overdose. NSOs are a leading
contributor to overdose deaths worldwide

Protonitazene is a potent NSO that is not often seen in Australia. It's around three
times more potent than fentanyl and can produce life-threatening toxic effects in
very small amounts.

What is Protonitazene?

As isotonitazene has only recently entered the European drug market, it is important
to be aware that since some laboratories do not routinely screen for the substance,
both its market presence and its role in serious adverse events (such as acute
poisonings that present to hospital emergency rooms and medico-legal death
investigations) may go undetected.

The fact that isotonitazene concentrations in biological samples are often low to
sub-nanogram per milliliter is another problem, and it emphasizes the necessity for
enhanced analytical sensitivity when testing for the substance.

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