Użytkownik "Iza" <i...@i...pl> napisał w wiadomości
news:a62roq$io5$1@okapi.ict.pwr.wroc.pl...
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> Glucotoxicity and lipotoxicity contribute to the impaired ß-cell function
> observed in type 2 diabetes. Here we examine the effect of saturated and
> unsaturated fatty acids at different glucose concentrations on ß-cell
> proliferation and apoptosis. Adult rat pancreatic islets were cultured onto
> plates coated with extracellular matrix derived from bovine corneal
> endothelial cells. Exposure of islets to saturated fatty acid (0.5 mmol/l
> palmitic acid) in medium containing 5.5, 11.1, or 33.3 mmol/l glucose for 4
> days resulted in a five- to ninefold increase of ß-cell DNA fragmentation.
> In contrast, monounsaturated palmitoleic acid alone (0.5 mmol/l) or in
> combination with palmitic acid (0.25 or 0.5 mmol/l each) did not affect DNA
> fragmentation. Increasing concentrations of glucose promoted ß-cell
> proliferation that was dramatically reduced by palmitic acid. Palmitoleic
> acid enhanced the proliferation activity in medium containing 5.5 mmol/l
> glucose but had no additional effect at higher glucose concentrations (11.1
> and 33.3 mmol/l). The cell-permeable ceramide analog C2-ceramide mimicked
> both the palmitic acid-induced ß-cell apoptosis and decrease in
> proliferation. Moreover, the ceramide synthetase inhibitor fumonisin B1
> blocked the deleterious effects of palmitic acid on ß-cell viability.
> Additionally, palmitic acid but not palmitoleic acid decreased the
> expression of the mitochondrial adenine nucleotide translocator and induced
> release of cytochrome c from the mitochondria into the cytosol. Finally,
> palmitoleic acid improved ß-cell-secretory function that was reduced by
> palmitic acid.

no i co ja tu czytam, ze tluszcze nasycone tu ich przedstawiciel
palmitic acid (promowane przez K) pwoduja nie dosc, ze fragmentacje DNA
beta komorek w trzystce, to jeszcze redukuja wydzielanie insuliny.

czytam teraz konkluzje

Taken together, these results suggest that the lipotoxic
> effect of the saturated palmitic acid involves an increased apoptosis rate
> coupled with reduced proliferation capacity of ß-cells and impaired insulin
> secretion.

iz kw nasycone, ktorych mamy pod dostatkiem w diecie K
zwieksza apoptoze kom, ktora jest polaczona ze zredukowana
mozliwoscia podzilow oraz uposledzona funkcja wydzielnicza
komorek beta.
tutaj moze podam zrodla tych kwasow ze strony AHA

Saturated fats
foods from animals
whole milk, cream, ice cream, whole-milk cheeses, butter, lard and meats

certain plant oils
palm, palm kernel and coconut oils, cocoa butter




In contrast, the monounsaturated palmitoleic acid
> does not affect ß-cell apoptosis, yet it promotes ß-cell proliferation at
> low glucose concentrations, counteracting the negative effects of palmitic
> acid as well as improving ß-cell function.

a tu efekt przeciwny nienasyconego kw tluszcowego.
czyli jak do tej pory przyklady na obowiazujace
w medycynie zasady, w tym przypadku wplyw tluszczy
na beta kom w trzustce.
iwon(k)a